Rifampicin

Rifampicin is a semisynthetic ansamycin antibiotic with potent activity against mycobacteria. It is a first-line agent for tuberculosis treatment and is also used for other bacterial infections.

**Properties**:
– Lipophilic with excellent tissue penetration
– Characteristic orange-red color
– Induces hepatic enzymes

**Applications**:
1. **Tuberculosis Therapy**: Key component of multi-drug regimens.
2. **MRSA Infections**: Used in combination therapy for resistant staphylococci.
3. **Prosthetic Infections**: Effective in treating biofilm-associated infections.

**Effects**:
– Inhibits bacterial RNA polymerase.
– Bactericidal against slow-growing organisms.
– Penetrates biofilms and intracellular compartments.